Your business: Research oriented

Drug discovery and development services are offered via a consortium of several independent Dutch companies called PRISNA BV (Product Isolation from Nature). We offer discovery, development and production of natural products, including extraction, separation, isolation, purification and structure elucidation or just fractionation of extracts.

The following services are available to its clients:

  • Contract research
  • Manufacturing of target compounds
  • Equipment distribution/support
  • GLP, GMP compliant (on request) including preparation of DMF’s and IMPD’s

Technologies:

  • Supercritical extraction (scCO2)
  • Centrifugal partition chromatography (FCPC)
  • Preparative HPLC, Flash Chromatography
  • NMR, LC/MS/DAD, GC/MS, UPLC/DAD
  • Cytochrome P450 metabolomic studies
  • Isotope labelled plant material (C13, N15)

The modern analytical equipment in the consortium is available for third parties. The following table summarizes the equipment and its intended use:

Equipment

Use

GMP CO2 unit

Extraction and formulation development + extraction of high value compounds in natural products such as nutraceuticals, cosmetics and pharmaceuticals

Overpress. water extraction

Extraction of plant material

LC-DAD & densitometry (TLC)

Analyses of complex plant extracts

Centrifugal Partitioning Chrom.

  • Nutraceutical
  • Fine chemical
  • Pharmaceutical
  • Bio-medical
  • Biotechnology
  • Fats and oils

Pharmaceutical raw materials + impurities
Ultra-pure compounds can be created from natural products
Innovative new products can be developed
Higher yields can be achieved
Product development is faster and less expensive
Integrity of the material's bioactivity is maintained
Higher throughput is achieved

Agilent 1100 LC-MSD, type SL

Residue analyses of pesticides, antibiotics etc (for instance in MRL studies)
Peak purity analyses (pharmaceutical development)
Pharmacokinetic analyses (PK studies)
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